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Peter Parker was just an average teenager until he took a field trip to Oscorp Inc. and he was bitten by a radioactive spider that gave him spider like characteristics. He entered in a wrestling match when his uncle was shot. He later discovered that Sandman killed his uncle by mistake.
Spiderman (Peter Parker) has many, many weaknesses. The big weakness that he has is his loyalty, Green Goblin, Doc Oc, and Venom all captured his girlfriend Mary Jane Watson.